Rectification in the smooth muscle cell membrane of rabbit aorta.
نویسندگان
چکیده
منابع مشابه
The Photoactivated Relaxation of Smooth Muscle of Rabbit Aorta
Smooth muscle of strips of rabbit aorta, placed in a state of active tonic contraction by addition of a stimulating drug, relaxes during exposure to light. The relaxation is reversible. The extent of relaxation produced by a standard exposure depends on the preexposure level of active contraction but not on the nature of the stimulating drug used to produce contraction. With strips brought to a...
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A procedure for dissociating the rabbit aorta into single, functional smooth muscle cells is described. After removal of adventitia and intima, slices of media were incubated with purified collagenase, elastase, and soybean trypsin inhibitor in a Krebs-Ringer buffer modified with Hepes, amino acids, and a [Ca2+] of 0.2 mM. After enzymatic digestion and mechanical shear, the yield of dispersed c...
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We evaluated the ability of the Ca2+ channel blocker nifedipine to influence the severity of atherosclerotic lesions and the pattern of aortic smooth muscle cell (SMC) differentiation in cholesterol-fed New Zealand White rabbits. The animals were fed a 1% cholesterol-enriched diet for 12 weeks. After 4 weeks of the diet, some rabbits were given nifedipine (20 mg b.i.d.) for another 8 weeks with...
متن کاملElectrophysiological Studies of the Smooth Muscle Cell Membrane of the Rabbit Common Carotid Artery
The electrical responses of the smooth muscle cells of the rabbit common carotid artery to extracellular stimulation were studied in isotonic and hypertonic solution (1.7 times normal tonicity) with microelectrodes. No spontaneous electrical or mechanical activity was recorded when the tissue was in either isotonic or hypertonic solution. The voltage-current relation of smooth muscle cells in t...
متن کاملDelayed Rectification and Anomalous Rectification in Frog's Skeletal Muscle Membrane
Delayed rectification was elicited in frog's skeletal muscles bathed in choline-Ringer's solution, in normal Ringer's solution with tetrodotoxin, in 40 mM Na(2)SO(4) solution with tetrodotoxin, and even in 40 mM K(2)SO(4) solution when the membrane had been previously hyperpolarized. However, after a sustained depolarization current-voltage relations in 40 mM K(2)SO(4) and in 40 mM Na(2)SO(4) s...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1976
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1976.sp011419